A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 19359265.
- Also identified by DOI 10.1136/jmg.2008.064956 and PMC identifier 2696823.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Telomere length is a predictor for a number of common age related diseases and is a heritable trait. To identify new loci associated with mean leukocyte telomere length we conducted a genome wide association study of 314,075 single nucleotide polymorphisms (SNPs) and validated the results in a second cohort (n for both cohorts combined = 2790). We identified two novel associated variants (rs2162440, p = 2.6 x 10(-6); and rs7235755, p = 5.5 x 10(-6)) on chromosome 18q12.2 in the same region as the VPS34/PIKC3C gene, which has been directly implicated in the pathway controlling telomere length variation in yeast. These results provide new insights into the pathways regulating telomere homeostasis in humans.
Medical subject headings
- Chromosomes, Human, Pair 18
- Genome-Wide Association Study
- Leukocytes
- Telomere
- Twins