The ups and downs of p53: understanding protein dynamics in single cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19360021.
- Also identified by DOI 10.1038/nrc2604 and PMC identifier 2892289.
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Abstract
Cells living in a complex environment must constantly detect, process and appropriately respond to changing signals. Therefore, all cellular information processing is dynamic in nature. As a consequence, understanding the process of signal transduction often requires detailed quantitative analysis of dynamic behaviours. Here, we focus on the oscillatory dynamics of the tumour suppressor protein p53 as a model for studying protein dynamics in single cells to better understand its regulation and function.
Medical subject headings
- Signal Transduction
- Tumor Suppressor Protein p53