Depression and heart rate variability in patients with coronary heart disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19376975.
- Also identified by DOI 10.3949/ccjm.76.s2.03 and PMC identifier PMC1924882.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Depression is common in patients with coronary heart disease (CHD) and is a risk factor for cardiac morbidity and mortality in these patients. Depression is associated with autonomic nervous system dysfunction, which may at least partially explain this increased risk. Low heart rate variability (HRV), which reflects excessive sympathetic and/or inadequate parasympathetic modulation of heart rate, is a strong predictor of mortality in patients with CHD. Most studies-both in patients with stable CHD and in patients with a recent acute coronary event-have found HRV to be lower in depressed patients than in their nondepressed counterparts. This manuscript provides an overview of this literature and concludes that HRV may account for a substantial part of the risk associated with depression in CHD.