Basic research models for the study of underlying mechanisms of electrical neuromodulation and ischemic heart-brain interactions.
basic_science · Level V
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- Record sourced from PubMed, PMID 19376982.
- Also identified by DOI 10.3949/ccjm.76.s2.09.
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Abstract
The study of mechanisms of action underlying the use of electrical neuromodulation for angina and myocardial ischemia may illuminate heart-brain interactions that influence these conditions. To investigate these mechanisms of action, we initiated a neurocardiology program in the 1990s. This review discusses the experimental models we have studied to unravel the heart-brain interactions involved in the use of electrical neuromodulation for ischemic disease.