Targeting DNA topoisomerase II in cancer chemotherapy.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19377506.
- Also identified by DOI 10.1038/nrc2607 and PMC identifier 2748742.
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Abstract
Recent molecular studies have expanded the biological contexts in which topoisomerase II (TOP2) has crucial functions, including DNA replication, transcription and chromosome segregation. Although the biological functions of TOP2 are important for ensuring genomic integrity, the ability to interfere with TOP2 and generate enzyme-mediated DNA damage is an effective strategy for cancer chemotherapy. The molecular tools that have allowed an understanding of the biological functions of TOP2 are also being applied to understanding the details of drug action. These studies promise refined targeting of TOP2 as an effective anticancer strategy.
Medical subject headings
- Antineoplastic Agents
- Enzyme Inhibitors
- Topoisomerase II Inhibitors