Interleukin-12 family members and type I interferons in Th17-mediated inflammatory disorders.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19383026.
- Also identified by DOI 10.1111/j.1398-9995.2009.02039.x.
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Abstract
Cytokines produced by antigen-presenting cells govern the fate of helper T-cell responses. Herein, we review the impact of interleukin (IL)-23 and IL-27 on the outcome of T-helper (Th) 17 cell responses and discuss their impact in the pathogenesis of T-cell-mediated inflammatory disorders of autoimmune or allergic origin. We then discuss how type I interferons might influence the course of autoimmune diseases by tipping the balance between IL-12 family members.
Medical subject headings
- Antigen-Presenting Cells
- Hypersensitivity
- Inflammation
- Interferon Type I
- Interleukin-12
- T-Lymphocytes, Helper-Inducer