Regulation of breast cancer metastasis by atypical chemokine receptors.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19383808.
- Also identified by DOI 10.1158/1078-0432.CCR-09-0141.
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Abstract
The interaction between chemokines and their G-protein-coupled receptors plays an important role in promoting metastasis of different kinds of human cancers. However, the expression of an atypical chemokine receptor, CCX-CKR, which serves as a decoy receptor to attract chemokines, inhibits the growth and metastasis of breast cancer by sequestration of chemokines.
Medical subject headings
- Breast Neoplasms
- Neoplasm Metastasis
- Receptors, CCR