Modulation of conduction velocity by nonmyocytes in the low coupling regime.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19389687.
- Also identified by DOI 10.1109/TBME.2008.2006028 and PMC identifier 3563360.
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Abstract
This paper explores the conditions under which nonmyocytes, when electrically coupled to myocytes, act as a passive load during the depolarization phase. Using theoretical arguments and numerical simulations in a tissue incorporating fibroblasts, the passive load approximation is shown to be accurate at low coupling conductances (< 2 nS). In this case, the effect on conduction velocity can be expressed as a function of the elevation in resting potential and the coupling only.
Medical subject headings
- Computer Simulation
- Heart Conduction System
- Models, Cardiovascular