Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19396160.
- Also identified by DOI 10.1038/nbt.1538.
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Abstract
We show that selection of drug-resistant bacterial mutants allows the discovery of antibacterial compounds. Mutant strains of a soil-isolated Streptomyces species that does not produce antibacterials synthesize a previously unknown class of antibacterial, which we name piperidamycin. Overall, 6% of non-Streptomyces actinomycetes species and 43% of Streptomyces species that do not produce antibacterials are activated to produce them. The antibacterial-producing mutants all carried mutations in RNA polymerase and/or the ribosomal protein S12.
Medical subject headings
- Anti-Bacterial Agents
- DNA-Directed RNA Polymerases
- Drug Discovery
- Mutation
- Ribosomal Proteins
- Streptomyces