Vincristine-induced recurrent laryngeal nerve paralysis in children.
case_report · Level V
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- Record sourced from PubMed, PMID 1939879.
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Abstract
Stridor developed in 2 children during vincristine therapy for malignancies. Indirect laryngoscopy revealed left vocal cord paralyses in both patients. One child had generalized neurotoxicity from vincristine including hypotonia, decreased gastrointestinal motility, and painful paresthesias while laryngeal nerve paralysis was the only neurotoxic manifestation in the other patient. Stridor resolved in both patients after discontinuing or decreasing the dose of vincristine. Visualization of the airway not only confirms the diagnosis, but also rules out treatable causes of stridor in the febrile, immunocompromised patient.
Medical subject headings
- Respiratory Sounds
- Vincristine
- Vocal Cord Paralysis