Virulence of rimantadine-resistant human influenza A (H3N2) viruses in ferrets.
basic_science · Level V
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Abstract
The influence of rimantadine-resistance mutations on the virulence of human H3N2 viruses in ferrets was examined. The similarities in virulence of the drug-resistant mutants with single amino acid substitutions at three different locations, 27, 30, and 31, within the M2 sequence and their corresponding sensitive wild-type isolates contrasted with differences in virulence between the three pairs of viruses. These data provide further evidence that rimantadine-resistant viruses that emerge during treatment of patients with the drug are unaltered both in their growth characteristics and virulence.
Medical subject headings
- Disease Models, Animal
- Ferrets
- Influenza A Virus, H3N2 Subtype
- Influenza A virus
- Orthomyxoviridae Infections
- Rimantadine