Biomolecular-motor-based nano- or microscale particle translocations on DNA microarrays.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19405509.
- Also identified by DOI 10.1021/nl901013k.
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Abstract
We aimed to create autonomous on-chip systems that perform targeted translocations of nano- or microscale particles in parallel using machinery that mimics biological systems. By exploiting biomolecular-motor-based motility and DNA hybridization, we demonstrate that single-stranded DNA-labeled microtubules gliding on kinesin-coated surfaces acted as cargo translocators and that single-stranded DNA-labeled cargoes were loaded/unloaded onto/from gliding microtubules at micropatterned loading/unloading sites specified by DNA base sequences. Our results will help to create autonomous molecular sorters and sensors.
Medical subject headings
- DNA, Single-Stranded
- Kinesins
- Microtubules
- Molecular Mimicry
- Nanoparticles
- Oligonucleotide Array Sequence Analysis