Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins.
basic_science · Level V
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- Record sourced from PubMed, PMID 19407142.
- Also identified by DOI 10.1126/science.1173041 and PMC identifier 2827199.
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Abstract
Type 2C protein phosphatases (PP2Cs) are vitally involved in abscisic acid (ABA) signaling. Here, we show that a synthetic growth inhibitor called pyrabactin functions as a selective ABA agonist. Pyrabactin acts through PYRABACTIN RESISTANCE 1 (PYR1), the founding member of a family of START proteins called PYR/PYLs, which are necessary for both pyrabactin and ABA signaling in vivo. We show that ABA binds to PYR1, which in turn binds to and inhibits PP2Cs. We conclude that PYR/PYLs are ABA receptors functioning at the apex of a negative regulatory pathway that controls ABA signaling by inhibiting PP2Cs. Our results illustrate the power of the chemical genetic approach for sidestepping genetic redundancy.
Medical subject headings
- Abscisic Acid
- Arabidopsis
- Arabidopsis Proteins
- Membrane Transport Proteins
- Naphthalenes
- Phosphoprotein Phosphatases
- Sulfonamides