Coated-platelet levels are low in patients with spontaneous intracerebral hemorrhage.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 19407225.
- Also identified by DOI 10.1161/STROKEAHA.109.549014.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Coated-platelets are a subset of platelets with high procoagulant potential observed on dual agonist stimulation with collagen and thrombin. Failure to produce coated-platelets in animals results in a bleeding diathesis. With this background, we undertook a pilot study to investigate coated-platelet production in patients with spontaneous intracerebral hemorrhage (SICH). Coated-platelet levels were determined in 26 patients with a diagnosis of SICH and 52 controls. The patient population had significantly lower coated-platelet levels than the controls (mean+/-SD, 24.8+/-9.7% versus 32.9+/-12.6%, P=0.0035). Decreased coated-platelet synthesis may be linked to the mechanisms involved in the events leading to SICH.
Medical subject headings
- Blood Platelets
- Cerebral Hemorrhage