Commonality but diversity in cancer gene fusions.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19410533.
- Also identified by DOI 10.1016/j.cell.2009.04.034.
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Abstract
Recent findings of gene fusions in carcinomas recapitulate the discovery of chromosomal abnormalities in leukemias and sarcomas decades ago. A recurring feature of carcinoma gene fusions, in contrast to those in hematopoietic and mesenchymal malignancies, is that they result in aberrant cell signaling. This may reflect differences in the differentiation programs of these tissues.
Medical subject headings
- Chromosome Aberrations
- Neoplasms
- Oncogene Fusion
- Oncogene Proteins, Fusion