Rfu1: stimulus for the ubiquitin economy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19410534.
- Also identified by DOI 10.1016/j.cell.2009.04.032.
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Abstract
During cellular stress, monoubiquitin is in demand due to the accumulation of misfolded proteins that require proteasomal degradation. Kimura et al. (2009) now show in yeast that monoubiquitin levels are bolstered during stress conditions by downregulation of the protein Rfu1, an inhibitor of the deubiquitinating enzyme Doa4.
Medical subject headings
- Endopeptidases
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins