Ure(k)a! Sirtuins Regulate Mitochondria.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19410538.
- Also identified by DOI 10.1016/j.cell.2009.04.036 and PMC identifier 3310393.
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Abstract
Increasing evidence suggests that multiple metabolic pathways are regulated by sirtuin-dependent protein deacetylation in the mitochondria. In this issue, Nakagawa et al. (2009) show that the sirtuin SIRT5 deacetylates and activates a mitochondrial enzyme, carbamoyl phosphate synthetase 1, which mediates the first step in the urea cycle.
Medical subject headings
- Carbamoyl-Phosphate Synthase (Ammonia)
- Mitochondria
- Sirtuins