Germline mutation of microRNA-125a is associated with breast cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19411564.
- Also identified by DOI 10.1136/jmg.2008.063123.
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Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that inhibit expression of specific target genes at the posttranscriptional level. MiRNAs are often found to be misregulated in human cancer, and they can act as either potent oncogenes or tumour suppressor genes. Here we show that a germline mutation in mature miR-125a is highly associated with breast cancer tumorigenesis, suggesting that miR-125a is likely to function as a tumour suppressor gene in human cancer.
Medical subject headings
- Breast Neoplasms
- Germ-Line Mutation
- MicroRNAs