Autoimmunity: CTLA-4: a key protein in autoimmunity.
Level V
Where this comes from
- Record sourced from PubMed, PMID 19412189.
- Also identified by DOI 10.1038/nrrheum.2009.77.
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Abstract
Studies performed during the past 2 years have provided a deeper understanding into the role of CTLA-4, which is expressed on regulatory T cells, in preventing autoimmunity, and also provide mechanistic insight into protein-based therapeutics such as abatacept for rheumatic diseases.
Medical subject headings
- Antigens, CD
- Autoimmunity
- T-Lymphocytes, Cytotoxic
- T-Lymphocytes, Regulatory