Atherogenesis on the chopping block.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19416707.
- Also identified by DOI 10.1016/j.cmet.2009.04.003.
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Abstract
Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) are now established features of the atherosclerotic plaque. In this issue, Thorp et al. (2009) provide initial insights into the causative relationship between UPR and the atherosclerotic disease process, specifically linking the proapoptotic mediator CHOP to plaque growth and necrosis.
Medical subject headings
- Atherosclerosis
- Endoplasmic Reticulum
- Transcription Factor CHOP