Live longer sans the AT1A receptor.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19416709.
- Also identified by DOI 10.1016/j.cmet.2009.04.002 and PMC identifier 2697617.
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Abstract
Excessive activation of the AT(1A) receptor (AT(1A)R) by angiotensin II (Ang II) is implicated in the age-related development of hypertension, diabetes, and kidney disease. AT(1A)R-deficient mice live longer and have lower levels of oxidative stress than wild-type mice (Benigni et al., 2009), suggesting a role for AT(1A)R signaling in the aging process.
Medical subject headings
- Longevity
- Receptor, Angiotensin, Type 1