Osteoclasts pump iron.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19416710.
- Also identified by DOI 10.1016/j.cmet.2009.04.005.
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Abstract
Osteoclasts are the primary cells that resorb bone; they require high energy levels to degrade bone matrix, releasing minerals to maintain calcium homeostasis. Recent work on osteoclast differentiation and activity highlights an important role for mitochondrial biogenesis and explores the role of iron transferrin in generating a positive osteoclastogenic feedback loop.
Medical subject headings
- Iron
- Osteoclasts
- Trans-Activators