Allergic bronchopulmonary aspergillosis after infliximab therapy for sarcoidosis: a potential mechanism related to T-helper cytokine balance.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 19420205.
- Also identified by DOI 10.1378/chest.08-2106.
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Abstract
We report a case of allergic bronchopulmonary aspergillosis (ABPA) that occurred in a man receiving infliximab for systemic sarcoidosis. His symptoms associated with ABPA were temporally related to his infliximab infusions. We suspect that infliximab disrupted the T-helper (Th) type 1-Th2 lymphocyte balance such that Th2 cytokines were left relatively unopposed, promoting the development of ABPA.
Medical subject headings
- Anti-Inflammatory Agents
- Antibodies, Monoclonal
- Aspergillosis, Allergic Bronchopulmonary
- Sarcoidosis