New roles revealed for T cells and DCs in glomerulonephritis.
expert_opinion · Level V
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- Record sourced from PubMed, PMID 19422093.
- Also identified by PMC identifier 2673880.
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Abstract
Little is known about the potential role of T cells in the inflammatory renal disease glomerulonephritis (GN). GN has been historically viewed as a product of immune complex-mediated complement activation, and the presence of autoantibodies made identifying T cell-specific effector contributions difficult to elucidate. In this issue of the JCI, Heymann et al. generate what they believe to be a novel, transgenic murine model of GN, demonstrating a direct role for CD8+ T cells, activated CD4+ T cells, and DCs in the pathogenesis of GN (see the related article beginning on page 1286).
Medical subject headings
- Dendritic Cells
- Disease Models, Animal
- Glomerulonephritis
- T-Lymphocytes