Tissue- and organ-selective biodistribution of NIR fluorescent quantum dots.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19422261.
- Also identified by DOI 10.1021/nl900872r and PMC identifier 2782558.
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Abstract
A significant portion of the field of nanomedicine is predicated on being able to target nanoparticles to sites of disease. However, in vivo biodistribution and clearance of nanoparticles are poorly understood. In this study, a novel formulation of near-infrared fluorescent InAs(ZnS) quantum dots was synthesized and coated with a systematically increasing chain length of PEG. We found that varying PEG chain length resulted in major changes in organ/tissue-selective biodistribution and clearance from the body.
Medical subject headings
- Quantum Dots