Interleukin-17A is not expressed by CD207(+) cells in Langerhans cell histiocytosis lesions.
basic_science · Level V
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- Record sourced from PubMed, PMID 19424201.
- Also identified by DOI 10.1038/nm0509-483 and PMC identifier 2820828.
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Abstract
Interleukin-17 (IL-17A) is a pro-inflammatory cytokine that has recently been implicated in pathogenesis of Langerhans Cell Histiocytosis (LCH), a potentially fatal disease characterized by lesions including CD207+ (langerin +) histiocytes. However, in this study we were unable to identify IL-17A gene expression in Langerhans cell lesions, and plasma levels of IL-17A did not correlate with disease activity. Therefore, this study does not support a central role for IL-17A in LCH pathogenesis.
Medical subject headings
- Antigens, CD
- Histiocytosis, Langerhans-Cell
- Interleukin-17
- Lectins, C-Type
- Mannose-Binding Lectins