Developmental regulation of hepatitis B virus biosynthesis by hepatocyte nuclear factor 4alpha.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19424486.
- Also identified by DOI 10.1371/journal.pone.0005489 and PMC identifier 2674568.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The host cellular factors that promote persistent viral infections in vivo are, in general, poorly understood. Utilizing the hepatitis B virus (HBV) transgenic mouse model of chronic infection, we demonstrate that the nuclear receptor, hepatocyte nuclear factor 4alpha (HNF4alpha, NR2A1), is essential for viral biosynthesis in the liver. The dependency of HBV transcription on HNF4alpha links viral biosynthesis and persistence to a developmentally regulated transcription factor essential for host viability.
Medical subject headings
- Growth and Development
- Hepatitis B virus
- Hepatocyte Nuclear Factor 4
- Virus Replication