Galpha(s) uncouples hematopoietic stem cell homing and mobilization.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19427288.
- Also identified by DOI 10.1016/j.stem.2009.04.009.
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Abstract
Defects of hematopoietic stem cell adhesion or migration generally lead to reduced homing to, and enhanced mobilization from, the bone marrow. In a recent publication in Nature, Adams et al. (2009) demonstrate that the guanine-nucleotide-binding stimulatory alpha subunit (Galpha(s)) can, unexpectedly, promote both phenomena.
Medical subject headings
- GTP-Binding Protein alpha Subunits, Gs
- Hematopoietic Stem Cells