Efavirenz treatment and false-positive results in benzodiazepine screening tests.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 19432553.
- Also identified by DOI 10.1086/599109.
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Abstract
We investigated the effect of efavirenz treatment on the results of drug screening tests of urine samples obtained from 100 patients infected with human immunodeficiency virus. Of 50 patients who received efavirenz, 49 tested positive for benzodiazepines in > or =1 drug screening test, whereas of 50 patients who did not receive efavirenz, only 1 tested positive for benzodiazepines in > or =1 drug screening test. The major metabolite 8-hydroxy-efavirenz is responsible for this cross-reactivity.
Medical subject headings
- Anti-HIV Agents
- Benzodiazepines
- Benzoxazines
- False Positive Reactions
- HIV Infections
- Substance Abuse Detection
- Substance-Related Disorders
- Urine