Intravenous tigecycline as adjunctive or alternative therapy for severe refractory Clostridium difficile infection.

Herpers, Bjorn L; Vlaminckx, Bart; Burkhardt, Olaf; Blom, Harmjo; Biemond-Moeniralam, Hazra S; Hornef, Mathias; Welte, Tobias; Kuijper, Edward J · Clin Infect Dis · 2009

case_series · Level IV

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Abstract

Clostridium difficile infection (CDI) has become more refractory to standard therapy. We describe 4 patients with severe refractory CDI who were successfully treated with tigecycline. Symptoms improved within 1 week. No relapses were observed. This favorable outcome suggests that tigecycline might be a useful alternative for treating severe refractory CDI.

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