p21 in cancer: intricate networks and multiple activities.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19440234.
- Also identified by DOI 10.1038/nrc2657 and PMC identifier 2722839.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
One of the main engines that drives cellular transformation is the loss of proper control of the mammalian cell cycle. The cyclin-dependent kinase inhibitor p21 (also known as p21WAF1/Cip1) promotes cell cycle arrest in response to many stimuli. It is well positioned to function as both a sensor and an effector of multiple anti-proliferative signals. This Review focuses on recent advances in our understanding of the regulation of p21 and its biological functions with emphasis on its p53-independent tumour suppressor activities and paradoxical tumour-promoting activities, and their implications in cancer.
Medical subject headings
- Cyclin-Dependent Kinase Inhibitor p21
- Neoplasms