Ablation of klotho and premature aging: is 1,25-dihydroxyvitamin D the key middleman?
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 19444269.
- Also identified by DOI 10.1038/ki.2009.55.
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Abstract
The reversal of soft-tissue abnormalities and prolonged lifespan observed in klotho(-/-) mice following genetic inactivation of 1alpha-hydroxylase underscores the pathophysiological role of 1,25-dihydroxyvitamin D in mediating some of the premature aging-like features observed in klotho(-/-) mice.
Medical subject headings
- Aging, Premature
- Gene Silencing
- Glucuronidase
- Vitamin D