Stress-induced oligomerization and chromosomal relocalization of heat-shock factor.
basic_science · Level V
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- Record sourced from PubMed, PMID 1944557.
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Abstract
The induction of heat-shock transcription factor (HSF) binding to DNA is accomplished by a heat-induced oligomerization. The transition to the induced state is accompanied by a chromosomal redistribution of HSF to the heat-shock puff sites. Over 150 additional chromosomal sites also accumulate HSF, including developmental loci that are repressed during heat shock. These findings suggest an unforeseen role for HSF as a repressor of normal gene activity during heat stress.
Medical subject headings
- Chromosomes
- DNA-Binding Proteins
- Drosophila
- Transcription Factors