Bringing DNA repair in tumors into focus.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19447863.
- Also identified by DOI 10.1158/1078-0432.CCR-09-0434.
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Abstract
Biomarkers are of crucial importance in optimizing cancer therapies. In this edition of Clinical Cancer Research, Bañuelos and colleagues assess H2AX phosphorylation as a predictive biomarker of response to DNA damaging agents. We discuss these results as well as the impact that double strand break repair biomarkers may have in cancer therapy.
Medical subject headings
- Cisplatin
- DNA Repair
- Dose Fractionation, Radiation
- Histones
- Neoplasms, Experimental