Netting neutrophils in autoimmune small-vessel vasculitis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19448636.
- Also identified by DOI 10.1038/nm.1959 and PMC identifier 2760083.
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Abstract
Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to antineutrophil cytoplasm autoantibodies (ANCAs). Here we show that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 (PR3) and myeloperoxidase (MPO). Deposition of NETs in inflamed kidneys and circulating MPO-DNA complexes suggest that NET formation triggers vasculitis and promotes the autoimmune response against neutrophil components in individuals with SVV.
Medical subject headings
- Autoimmune Diseases
- Microcirculation
- Neutrophils
- Vasculitis