Shedding UV light on alternative splicing.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19450507.
- Also identified by DOI 10.1016/j.cell.2009.04.054.
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Abstract
After DNA damage, cells modulate pre-messenger RNA (pre-mRNA) splicing to induce an anti- or proapoptotic response. In this issue, Muñoz et al. (2009) uncover a cotranscriptional mechanism for activating alternative pre-mRNA splicing after ultraviolet irradiation that depends unexpectedly on hyperphosphorylation of the RNA polymerase II C-terminal domain and decreased rates of transcription elongation.
Medical subject headings
- Alternative Splicing
- RNA Polymerase II
- Ultraviolet Rays