The CULt of caspase-8 ubiquitination.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19450509.
- Also identified by DOI 10.1016/j.cell.2009.04.052.
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Abstract
Caspase-8 is activated at the plasma membrane by the death-inducing signaling complex (DISC). Jin et al. (2009) show that polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC.
Medical subject headings
- Caspase 8
- Cullin Proteins