Abate and switch: miR-145 in stem cell differentiation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19450510.
- Also identified by DOI 10.1016/j.cell.2009.04.059.
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Abstract
MicroRNAs have been implicated as regulators of embryonic stem (ES) cell self-renewal and pluripotency. In this issue, Xu et al. (2009) demonstrate that miR-145 facilitates ES cell differentiation by repressing the core pluripotency factors OCT4, SOX2, and KLF4, thereby silencing the self-renewal program.
Medical subject headings
- Cell Differentiation
- Embryonic Stem Cells
- MicroRNAs