The nonphosphorylated form of RNA polymerase II preferentially associates with the preinitiation complex.
basic_science · Level V
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- Record sourced from PubMed, PMID 1946417.
- Also identified by PMC identifier 52855.
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Abstract
The two forms of RNA polymerase II that exist in vivo, phosphorylated (IIO) and nonphosphorylated (IIA), were purified to apparent homogeneity from HeLa cells. The nonphosphorylated form preferentially binds to the preinitiation complex. RNA polymerase II in the complex was converted by a cellular protein kinase to the phosphorylated form.
Medical subject headings
- DNA, Viral
- Isoenzymes
- Protein Kinases
- RNA Polymerase II
- Transcription Factors