SNCA variants are associated with increased risk for multiple system atrophy.
case_control · Level III
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- Record sourced from PubMed, PMID 19475667.
- Also identified by DOI 10.1002/ana.21685 and PMC identifier 3520128.
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Abstract
To test whether the synucleinopathies Parkinson's disease and multiple system atrophy (MSA) share a common genetic etiology, we performed a candidate single nucleotide polymorphism (SNP) association study of the 384 most associated SNPs in a genome-wide association study of Parkinson's disease in 413 MSA cases and 3,974 control subjects. The 10 most significant SNPs were then replicated in additional 108 MSA cases and 537 controls. SNPs at the SNCA locus were significantly associated with risk for increased risk for the development of MSA (combined p = 5.5 x 10(-12); odds ratio 6.2) [corrected].
Medical subject headings
- Genetic Predisposition to Disease
- Multiple System Atrophy
- Polymorphism, Single Nucleotide
- alpha-Synuclein