Brain-derived nerve growth factor in the treatment of sensorineural hearing loss.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19479743.
- Also identified by DOI 10.1002/lary.20515.
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Abstract
A possible medical treatment for sensorineural hearing loss using brain-derived nerve growth factor (BDNF) was explored. The hypothesis is that direct intracochlear application of BDNF will result in improved hearing. Animal research study. Significant hearing loss was created using cisplatin in 11 guinea pigs. One month later, bilateral cochleostomies were performed placing 0.05 microg of BDNF in one cochlea of each animal prior to plugging with connective tissue. The other cochlea served as a control. Auditory brain-stem response (ABR) testing was then carried out for three months at 6,000, 8,000, 12,000, and 24,000 Hz. ABR thresholds were better in the treated ear for all frequencies. Threshold differences were statistically significantly better two months after treatment (general linear model, repeated measures P = .045). Intracochlear application of BDNF may prevent hearing loss.
Medical subject headings
- Auditory Threshold
- Brain-Derived Neurotrophic Factor
- Cochlea
- Hearing Loss, Sensorineural