Twist: a new link from hypoxia to fibrosis.
Level V
Where this comes from
- Record sourced from PubMed, PMID 19483748.
- Also identified by DOI 10.1038/ki.2009.102.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Sun et al. demonstrate that hypoxia causes epithelial-to-mesenchymal transition by activating Twist, a transcription factor known to mediate both acquisition of a mesenchymal phenotype and resistance to apoptosis in cancer cells. This study provides clues as to how hypoxia and transforming growth factor-beta can collaborate to drive renal fibrogenesis.
Medical subject headings
- Kidney Diseases
- Twist-Related Protein 1