Metformin and insulin meet in a most atypical way.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19490902.
- Also identified by DOI 10.1016/j.cmet.2009.05.007.
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Abstract
A recent Cell paper by He et al. (2009) shows how metformin circumvents a block between insulin and atypical protein kinase C in obese and diabetic mice to inhibit gluconeogenesis by stimulating the phosphorylation of CBP and the disassembly of the CREB transcriptional complex.
Medical subject headings
- Hypoglycemic Agents
- Insulin
- Metformin