Cost-effectiveness of early one-year colonoscopy surveillance after polypectomy.

Abstract

Some colorectal cancers have been unexpectedly diagnosed within one year after polypectomy in high-quality trials. The purpose of this study was to assess the clinical and economic impact of early surveillance colonoscopy one year after polypectomy in relation to detection of colorectal cancer. A decision analysis model was constructed to compare strategies of performing or not performing one-year endoscopic surveillance in 60-year-old patients who underwent an initial endoscopic polypectomy. Outcome measures included the number of early colonoscopies needed to detect one case of cancer and to prevent one cancer-related death and the incremental cost-effectiveness ratio. The number of early one-year colonoscopies needed to detect one cancer and to prevent one cancer-related death was 354 and 1,437, respectively. The incremental cost-effectiveness ratio of performing early one-year colonoscopy as compared with not performing it was $66,136 per life-year gained. Current guidelines for postpolypectomy surveillance are relatively inefficient in excluding a clinically meaningful colorectal cancer risk at one year after polypectomy.