Tissue targeting in cancer: eIF4E's tale.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 19509132.
- Also identified by DOI 10.1158/1078-0432.CCR-09-0552.
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Abstract
The eukaryotic translation initiation factor eIF4E is elevated in many human cancers. Tissue-specific targeting of eIF4E activity in ovarian cancer cells is achieved in cell culture and in mice by fusing a peptide corresponding to the eIF4E inhibitor, the eIF4E binding protein 1 (BP1), to an agonist of the gonadotropin receptor.
Medical subject headings
- Antineoplastic Agents
- Drug Delivery Systems
- Eukaryotic Initiation Factor-4E
- Ovarian Neoplasms