Matrix metalloproteinase-2 gene variants and abdominal aortic aneurysm.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 19515587.
- Also identified by DOI 10.1016/j.ejvs.2009.04.019.
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Abstract
To investigate associations between two polymorphisms of the matrix metalloproteinase-2 gene (MMP2) and the incidence and progression of abdominal aortic aneurysm (AAA). Cases and controls were recruited from a trial of screening for AAAs. The association between two variants of MMP2 (-1360C>T, and +649C>T) in men with AAA (n=678) and in controls (n=659) was examined using multivariate analyses. The association with AAA expansion (n=638) was also assessed. In multivariate analyses with adjustments for multiple testing, no association between either SNP and AAA presence or expansion was detected. MMP2 -1360C>T and +649C>T variants are not risk factors for AAA.
Medical subject headings
- Aortic Aneurysm, Abdominal
- Matrix Metalloproteinase 2
- Polymorphism, Single Nucleotide