Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19517013.
- Also identified by DOI 10.1371/journal.pone.0005880 and PMC identifier 2690692.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Deviation from proper muscle development or homeostasis results in various myopathic conditions. Employing genetic as well as chemical intervention, we provide evidence that a tight regulation of Wnt/beta-catenin signaling is essential for muscle fiber growth and maintenance. In zebrafish embryos, gain-of-Wnt/beta-catenin function results in unscheduled muscle progenitor proliferation, leading to slow and fast muscle hypertrophy accompanied by fast muscle degeneration. The effects of Wnt/beta-catenin signaling on fast muscle hypertrophy were rescued by misexpression of Myostatin or p21(CIP/WAF), establishing an in vivo regulation of myofibrillogenesis by Wnt/beta-catenin signaling and Myostatin. Epistatic analyses suggest a possible genetic interaction between Wnt/beta-catenin and Myostatin in regulation of slow and fast twitch muscle myofibrillogenesis.
Medical subject headings
- Gene Expression Regulation
- Gene Expression Regulation, Developmental
- Muscle Fibers, Fast-Twitch
- Muscle Fibers, Slow-Twitch
- Muscles
- Myostatin
- Wnt Proteins
- Zebrafish
- beta Catenin