Parafibromin--functional insights.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19522828.
- Also identified by DOI 10.1111/j.1365-2796.2009.02107.x.
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Abstract
Parafibromin is a predominantly nuclear protein with a tumour suppressor role in the development of hereditary and nonhereditary parathyroid carcinomas, and the hyperparathyroidism-jaw tumour syndrome, which is associated with renal and uterine tumours. Parafibromin is a component of the highly conserved PAF1 complex, which regulates transcriptional events and histone modifications. The parafibromin/PAF1 complex regulates genes involved in cell growth and survival, and via these, parafibromin plays a pivotal role in embryonic development and survival of adults.
Medical subject headings
- Neoplasm Proteins
- Tumor Suppressor Proteins