Jagged gives endothelial tip cells an edge.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19524499.
- Also identified by DOI 10.1016/j.cell.2009.05.024.
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Abstract
Sprouting blood vessels have tip cells that lead and stalk cells that follow. Benedito et al. (2009) now show that competition between endothelial cells for the tip position is regulated by glycosylation of Notch receptors and by the opposing actions of the Notch ligands Jagged1 and Delta-like 4.
Medical subject headings
- Blood Vessels
- Calcium-Binding Proteins
- Endothelial Cells
- Intercellular Signaling Peptides and Proteins
- Membrane Proteins
- Neovascularization, Physiologic