Prion topology and toxicity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19524502.
- Also identified by DOI 10.1016/j.cell.2009.05.041.
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Abstract
Inactivation of mahogunin, an E3 ubiquitin ligase, causes a spongiform encephalopathy resembling prion disease. Chakrabarti and Hegde (2009) now report that prion proteins with aberrant topologies inactivate mahogunin, providing a plausible explanation for certain aspects of prion pathology.
Medical subject headings
- PrPC Proteins
- Prion Diseases